The gameplay and itemization of the original Diablo 2 have been brought back in Diablo 2 Resurrected, including the use of runewords. The process of creating runewords involves inserting specific runes into specific item types, which results in powerful and one-of-a-kind properties for the runeword. A few of the most powerful runewords in Diablo 2 Resurrected are as follows:

Enigma: Jah + Ith + BerIn order to create this runeword, the runes Jah, Ith, and Ber must first be inserted into a body armor. Enigma provides a number of beneficial stat bonuses, including an increase of +2 to all skills, an increase of +45% in run and walk speed, and an increase of +1 to teleport. It also grants a beneficial bonus to mana and life, as well as the ability to transform into a ghostly form that is invisible to both walls and foes.

Infinity: "Ber" plus "Mal" plus "Ber" plus "Est"A polearm or a spear must have the runes of Ber, Mal, Ber, and Ist inserted into it for the infinity rune to be created. This runeword grants a large bonus to lightning damage and a chance to cast the Conviction aura, which reduces the resistance of nearby foes to all elements. Additionally, the lightning damage bonus is increased by a significant amount. In addition to that, it increases your mana pool and gives you a chance to cast Static Field on any enemies that you hit.

The call to arms is as follows: Amn + Ral + Mal + Ist + OhmA weapon can become imbued with the power of this runeword by having the Diablo 2 Non-Ladder Items Amn, Ral, Mal, and Ist inserted into it. The ability "Call to Arms" grants the user a number of beneficial bonuses, including an increase of +1 to all skills, +2 to all attributes, and +40% to attack speed. In addition to this, it has the capacity to bestow upon party members a potent Battle Command aura that increases their damage and attack rating.

Fortitude: El + Sol + Dol + LoThe Diablo 2 Non-Ladder Items El, Sol, Dol, and Lo must be placed within a body armor in order to create the attribute of fortitude. This runeword provides a significant bonus to both the attack rating and the damage dealt, in addition to a bonus to both life and mana. In addition to this, there is a chance that you will cast the Chilling Armor spell, which slows down enemies in the area and increases your defense.

Eth times Tir times Lo times Mal times Ral equals Grief. A sword or an axe can be enchanted with the Grief rune by having the Eth, Tir, Lo, and Mal Diablo 2 Non-Ladder Items inserted into it. This runeword grants a significant increase to damage and attack rating, in addition to a chance to cast Venom on enemies that are damaged by the user's attacks. Additionally, it has the ability to grant a bonus to attack speed as well as a bonus to damage proportional to the level of your character.

These runewords are among the best in Diablo 2 Resurrected and have the potential to grant significant benefits to those players who are able to obtain them. However, keep in mind that creating runewords is a challenging and expensive process, and as a result, runewords might not be available to all players.